Strong spin-exchange recombination of three weakly interacting 7Li atoms

We reveal a significant spin-exchange pathway in the three-body recombination process for ultracold lithium-7 atoms near a zero-crossing of the two-body scattering length. This newly discovered recombination pathway involves the exchange of spin between all three atoms, which is not included in many theoretical approaches with restricted spin structure. Taking it into account, our calculation is in excellent agreement with experimental observations. To contrast our findings, we predict the recombination rate around a different zero-crossing without strong spin-exchange effects to be two orders of magnitude smaller, which gives a clear advantage to future many-body experiments in this regime. This work opens new avenues to study elementary reaction processes governed by the spin degree of freedom in ultracold gases

The multichannel nature of three-body recombination for ultracold 39^{39}K

We develop a full multichannel spin model in momentum space to investigate three-body recombination of identical alkali-metal atoms colliding in a magnetic field. The model combines the exact three-atom spin structure and realistic pairwise atom-atom interactions. By neglecting the interaction between two particles when the spectating particle is not in its initial spin state we arrive at an approximate model. With this approximate model we achieve excellent agreement with the recent precise measurement of the ground Efimov resonance position in potassium-39 close to 33.58 G [Chapurin $et$ $al$., Phys. Rev. Lett. 123, 233402 (2019)]. We analyze the limitations of our approximation by comparing to the numerical results for the full system and find that it breaks down for Feshbach resonances at larger magnetic fields in the same spin channel. There the relevant three-body closed channel thresholds are much closer to the open channel threshold, which enhances the corresponding multichannel couplings. Therefore the neglected components of the interaction should be included for those Feshbach resonances

An MR-compatible antenna and application in a murine superficial hyperthermia applicator

In this work, a novel magnetic resonance (MR)-compatible microwave antenna was designed and validated in a small animal superficial hyperthermia applicator. The antenna operates at 2.45 GHz and matching is made robust against production and setup inaccuracies. To validate our theoretical concept, a prototype of the applicator was manufactured and tested for its properties concerning input reflection, sensitivity for setup inaccuracies, environment temperature stability and MR-compatibility. The experiments show that the applicator indeed fulfils the requirements for MR-guided hyperthermia investigation in small animals: it creates a small heating focus (<1 cm3), has a stable and reliable performance (S11< −15 dB) for all working conditions and is MR-compatible

Transferases in Biocatalysis

Enzymes are nature’s catalyst of choice for the highly selective and efficient coupling of carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial glycosylation reactions, since chemical synthetic routes require extensive use of laborious protection group manipulations and often lack regio- and stereoselectivity.BT/Biocatalysi

Efficient three-body calculations with a two-body mapped grid method

We investigate the prospects of combining a standard momentum space approach for ultracold three-body scattering with efficient coordinate space schemes to solve the underlying two-body problem. In many of those schemes the two-body problem is numerically restricted up to a finite interparticle distance rb. We analyze effects of this two-body restriction on the two- and three-body level using pairwise square-well potentials that allow for analytic two-body solutions and more realistic Lennard-Jones van der Waals potentials to model atomic interactions. We find that the two-body t-operator converges exponentially in rb for the square-well interaction. Setting rb to 2000 times the range of the interaction, the three-body recombination rate can be determined accurately up to a few percent when the magnitude of the scattering length is small compared to rb, while the position of the lowest Efimov features is accurate up to the percent level. In addition we find that with the introduction of a momentum cut-off, it is possible to determine the three-body parameter in good approximation even for deep van der Waals potentials

Early treatment with intravenous lipid emulsion in a potentially lethal hydroxychloroquine intoxication

This case report describes the possible benefit of intravenous lipid emulsion in two patients surviving a severe intoxication with hydroxychloroquine in a dose that was previously considered to be lethal. The first case involves a 25-year-old female who ingested 17.5 grams of hydroxychloroquine, approximately one hour before presentation. An ECG showed QRS widening and the lab results showed hypokalaemia. She became unconscious, and developed hypotension and eventually apnoea. After intubation, supportive care consisted of norepinephrine and supplementation of potassium. Moreover, sodium bicarbonate and intravenous lipid emulsion were started to prevent cardiac toxicity. After these interventions, haemodynamic stability was established within a few hours. Although cardiomyopathy was confirmed, the patient recovered after two weeks. The second case concerns a 25-year-old male who took 5 grams of hydroxychloroquine. At presentation, two hours after intake, he showed QTc prolongation and hypokalaemia. The patient was treated with the usual supportive care and, although presentation to hospital was later, with intravenous lipid emulsion. Also this patient recovered. In conclusion, these cases show the benefit of supplemental intravenous lipid emulsion to prevent cardiac toxicity after a severe intoxication with hydroxychloroquine

Enzyme-Catalyzed Synthesis of Esters in Water

MsAcT catalyzes the esterification of primary alcohols in water. When utilizing acid and alcohol as starting materials low yields dictated by thermodynamics were observed. However, with activated esters such as ethyl acetate and vinyl acetate very high yields of the desired ester can be achieved in combination with the appropriate alcohol. This study investigated both the intrinsic kinetic properties of MsAcT for the hydrolysis and transesterification of esters in water as well as the thermodynamics of the reaction. In comparison to the chemical or enzymatic ester synthesis using either toxic reagent, and harsh organic solvents, the MsAcT-catalyzed synthesis of esters of primary alcohols can be achieved efficiently in water without neutralization steps.BT/BiocatalysisEKL Processin